Fmoc-PEG2-C2-NHS ester, with a molecular formula of C26H28N2O8 and molecular weight of 496.51, is a PEG-based PROTAC linker. It is primarily used in the synthesis of PROTACs (Proteolysis Targeting Chimeric Molecules). PROTACs are designed with two distinct ligands connected by a linker; one ligand binds to an E3 ubiquitin ligase, and the other targets a specific protein. This mechanism leverages the intracellular ubiquitin-proteasome system to facilitate the selective degradation of target proteins. This product is intended for research and analytical applications.
- PROTAC linker for targeted protein degradation
- Utilizes the ubiquitin-proteasome system
- Store pure form at -20°C for 3 years
- Store in solvent at -80°C for 6 months, -20°C for 1 month